Abnormal red cell membrane phosphatase activity in Beta-thalassemia
نویسندگان
چکیده
منابع مشابه
Prevalence and specificities of red cell alloantibodies in transfusion-dependent beta thalassemia patients in Yazd
Abstract Background Multiple transfusions in thalassemia patients may lead to antibody production against blood group antigens and hemolytic transfusion reaction might occur. In this study, antibody screening test was performed by tube and gel methods to determine the prevalence and specificity of alloantibodies in thalassemia patients. Materials and Methods In this cross-sectional study, overa...
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In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-thalassemia, as well as a transgenic (thalassemic-sickle) mouse that expresses ...
متن کاملAbnormal assembly of membrane proteins in erythroid progenitors of patients with beta-thalassemia major.
The life threatening anemia in beta-thalassemia major (Cooley's anemia) is characterized by profound intramedullary lysis, the cause of which is incompletely understood. Using marrow obtained from beta thalassemia major patients undergoing allogeneic bone marrow transplantation in Pesaro Italy, it became possible to directly study the mechanism of the intramedullary hemolysis. Based on our prev...
متن کاملDiagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT)
Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study. Correspond...
متن کاملprevalence and specificities of red cell alloantibodies in transfusion-dependent beta thalassemia patients in yazd
abstract background multiple transfusions in thalassemia patients may lead to antibody production against blood group antigens and hemolytic transfusion reaction might occur. in this study, antibody screening test was performed by tube and gel methods to determine the prevalence and specificity of alloantibodies in thalassemia patients. materials and methods in this cross-sectional study, overa...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1980
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198012000-00104